Meyd-873 __link__ [Direct ✧]

This is the main event. Honma specializes in playing refined, elegant women with hidden fires. Her micro-expressions—the slight lip bite, the averted eyes, the trembling hands—sell the “I shouldn’t want this, but I desperately do” conflict perfectly.

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| Phase | Design | Target Population | Primary Endpoint | Expected Milestones | |-------|--------|-------------------|------------------|---------------------| | (dose‑finding, safety) | Open‑label, 3‑plus‑3 escalation → expansion cohorts | KRAS‑G12D+ solid tumors (pancreatic, colorectal, NSCLC) with RAF‑DimerScore ≥ 2 | ORR (RECIST v1.1) + safety | IND filing Q3 2024 → First patient in Q1 2025 | | Phase 2b (confirmatory) | Randomized, double‑blind, MEYD‑873 + standard chemo vs. chemo alone | Same as above | PFS, OS, and biomarker‑driven subgroup analysis | Topline data Q4 2026 | | Phase 3 (global pivotal) | Multi‑regional, double‑blind | KRAS‑G12D+/RAF‑high metastatic pancreatic adenocarcinoma (primary) and KRAS‑G12D+ NSCLC (secondary) | OS superiority | NDA submission Q2 2029 | The adult entertainment industry is a global phenomenon,